Evaluation of antimicrobial and anticancer properties of finger millet (Eleusine coracana) and pearl millet (Pennisetum glaucum) extracts
Nidhi Singh, Meenu G, Anamika Sekhar and Jayanthi Abraham
Phenolic acids from finger millet (Eleusine coracana) and pearl millet (Pennisetum glaucum) were isolated as fractions in an organic solvent and their anticancer and antimicrobial properties were evaluated. Antimicrobial properties were studied using Kirby Bauer well diffusion technique and the polyphenols of millet showed antimicrobial activity onEscherichia coli, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, Klebsiella pneumoniae, Shigella dysenteriae, Enterococcus sp. and Salmonellasp. GC-MS analysis was done to confirm the compounds present in the extract. The cytotoxicity assay was done to screen for the anticancer activity against HepG2 hepatic cancer cell lines. Further, in silico studies were performed using AutoDock 4.0 to validate the antimicrobial results obtained. From the observation, it could be inferred that millet polyphenols of millets could be used as a natural source of antimicrobials and antioxidants, especially for minimizing the risk of diseases arising from oxidative deterioration and also cytotoxic effects.
(a) 3D complex of Pseudomonas aeruginosa topoisomerase and ligand interactions. (b) 2D Ligplot showing the bond length and hydrogen bonds.
How to cite this article:
Nidhi Singh, Meenu G, Anamika Sekhar, Jayanthi Abraham. Evaluation of antimicrobial and anticancer properties of finger millet (Eleusine coracana) and pearl millet (Pennisetum glaucum) extracts. Pharma Innovation 2015;3(11):82-86.