Vol. 3, Issue 11 (2015)

Author(s):
Haala M. Gabra, Mohammed E. Tageldin, Elmutuz H. Elssaig, Hani K. Fahmi, Nour M. Abdelateif, Sharif A. Elgoul

Abstract:
Introduction: Helicobacter pylori is associated with severe gastrointestinal pathologies. Moreover, it may cause an extra gastrointestinal disease such as atherosclerosis, insulin resistance, diabetes mellitus and some autoimmune diseases. 
Aim To investigate the relation between Helicobacter pylori infection and Insulin Resistance in Sudanese healthily subjects. 
Methods: In a case control study conducted in the period from May 2013 to May 2014, a total of a hundred and twenty patients were enrolled in this study; these patients were divided into two groups by matching age, sex. Group (A) patients were Helicobacter pylori positive. Group (B) subjects were Helicobacter pylori negative. The homeostasis model assessment (HOMA) was used to assess insulin resistance.
Results: In the present study, there was a statistically significant association betweenHelicobacter pylori positive patients (80/120; 66.67%) and insulin resistance (IR) compared toHelicobacter pylori negative patients (40/120; 33.33%) (P value <0.001). The mean value of IR was 3.21 ± 1.26, 2.05 ± 1.20 respectively, for Helicobacter pylori positive and Helicobacter pylori negative patients.
There was no statistical significant difference between Helicobacter pylori positive andHelicobacter Pylori negative patients as regard to other investigations (P value >0.05).
Conclusion: The findings confirm the existence of an association between infection withHelicobacter pylori and insulin resistance.