Vol. 3, Issue 11 (2015)

Author(s):
Sm Faysal Bellah, Md. Iqubal Hossain Raju, SM Saker Billah, Shaikh Emdadur Rahman, G.M.M. Murshid, Md. Mustafizur Rahman

Abstract:
In the present study crude ethanolic extract of the leaf of Feronia limonia was investigated for possible pharmacological activity. The biological interest of these compounds, coupled with the use of this plant in traditional medicine prompted us to check Feronia limoniafor antibacterial and antidiarrhoeal activity. The antibacterial activity of the ethanolic extract was investigated against ten microorganisms and showed moderate antibacterial activity against Staphylococcus saprophyticus, Staphylococcus pyogenes, Escherichia coli, Shigella boydii, Shigella dysentery and Shigella  flexneri; maximum zone of inhibition was found forShigella boydii (9 mm), Shigella dysentery (9 mm)  and Shigella  flexneri (9 mm) at 500 μg/disc. Feronia limonia extract produced a moderate reduction in the severity & frequency of diarrhoea produced by castor oil in mice compared with the standard drug loperamide (25 mg/kg). The antidiarrhoeal activity was found statistically significant (p<0.02 and p<0.001). The study clearly supports the medicinal value of this plant.