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Vol. 3, Issue 8 (2014)

Antimutagenic effect of Kenyan Tea cultivars in a bacterial test system

Author(s):
Karori Mbuthia, Francis Wachira, Raphael Ngure, Paul Mireji and Sabina Wachira
Abstract:
The antimutagenic effects of the aqueous tea extracts from Kenyan black, green and purple cultivars were evaluated by the Ames test using Salmonella typhimurium tester strains TA 1538. Results obtained showed that tea had no toxicity or mutagenic activity at a concentration of 20% (w/v) unlike the mutagen sodium azide. However, using the formulae, percentage inhibition = [1-T/M] ×100 where T is number of revertants per plate in presence of mutagen and test sample and M is number of revertants per plate in positive control, tea extracts had a significant (P<0.05) antimutagenic activity where the percent inhibition was 65% for green tea, 38% for purple tea and 19.17% for black tea. This was attributed to the radical scavenging activity of polyphenols. There is need therefore to carry out further research to help understand the precise  mechanism of action especially for black and purple teas, and to explore other beneficial effects that these polyphenols may have, before they can be adopted for therapeutic use.
Pages: 94-100  |  1005 Views  9 Downloads
How to cite this article:
Karori Mbuthia, Francis Wachira, Raphael Ngure, Paul Mireji, Sabina Wachira. Antimutagenic effect of Kenyan Tea cultivars in a bacterial test system. Pharma Innovation 2014;3(8):94-100.
The Pharma Innovation Journal