Vol. 3, Issue 7 (2014)

Author(s):
Vivek Kahale, Amrapali Mhaiskar, Priyanka Shelat, Pooja RU, Gaikwad NJ, Mundhada DR.

Abstract:
The relevant doses of Berberine administration in present preclinical study states that neurotoxicity induced by 6-Hydroxydopamine is remarkably neuroprotective in male wistar rats. 6-Hydroxydopamine induce Parkinson's disease (PD) which is a chronic and progressive neurodegenerative disease with loss of brown pigment neuromelanin with preferential loss of dopaminergic neurons of the substantia nigra pars compacta results in oxidative stress and mitochondrial disfunction. Berberine (BER) (2, 3-methylenedioxy-9, 10-dimethoxy protoberberine chloride) is an isoquinoline alkaloid from dried herb acts as a antioxidant and prevent reactive oxygen species (ROS) injury in various ways. Berberine treatments protects behavioral changes, significantly reduce oxidative damage & improved mitochondrial complex enzymes activities in different regions (striatum, cortex and hippocampus) of rat brain due to neurotoxicity. Administration of 6-Hydroxydopamine through I.C.V. produces hypo activity that resembles juvenile onset and advanced Parkinson's disease in rats. Berberine activity investigates the neuroprotective effect in animal model of Parkinson's disease.