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Vol. 3, Issue 7 (2014)

To study clinical trial comparing adapalene and tazarotene, two topical retinoids for acne vulgaris

Author(s):
Dr. Sachin Devendrarao Shende and Dr. Pinninti Srivalli
Abstract:
Introduction and objectives: Acne vulgaris is a very prevalent skin condition, especially among teenagers. Although there is no immediate danger to one's life, acne can lead to significant discomfort. This study aims to examine the effectiveness of two topical acne treatments: adapalene and tazarotene.
Materials and Methods: For the aforementioned study, 80 patients of either sex were enrolled and randomly assigned. It was an open, prospective, single-blind, randomised clinical experiment. It was conducted from July 2013 to August 2014 at Department of Dermatology, Maharajah’s Institute of Medical Sciences, Nellimarla, Vizianagaram, Andhra Pradesh, India.
Results: There was a larger decrease in both inflammatory and non-inflammatory acne lesions, and patients in this group had a moderate to good response. After 4 weeks, acne lesions had reduced by 25% and by 8 weeks, they had reduced by 60%. A moderate to good response was noted at the conclusion of the 12-week therapy period, with a reduction of 80.3%. Only a small percentage of participants experienced the potential side effects, which included skin peeling, redness, irritation, dryness, and itching. In comparison to topical 0.1% tazarotene cream, their side effects were minor and short-lived. Both patient compliance and treatment outcomes were positively impacted by the topical 0.1% adaplene cream. Regular and proper care was provided by patients.
Conclusion: Acne vulgaris was more common in men than females in this study. In both sexes, the incidence was highest in those between the ages of 15 and 20. Acne vulgaris was found to be quite common among students in this study.
Pages: 109-112  |  109 Views  56 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. Sachin Devendrarao Shende, Dr. Pinninti Srivalli. To study clinical trial comparing adapalene and tazarotene, two topical retinoids for acne vulgaris. Pharma Innovation 2014;3(7):109-112.

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