Redox-dependent Markers for Response to Neoadjuvant Radiotherapy for Rectal Cancer
Volodymyr V. Golotyuk, Anatoliy P. Burlaka
Biopsy materials of tumors and urine samples from 26 patients with rectal adenocarcinoma of the stage Т2-4N0M0 have been examined. In the first phase of treatment, patients received a preoperative course of radiotherapy to the tumor to a total focal dose of 39 Gy (single focal dose 3 Gy with 13 sessions during 2.5 weeks). A radical surgical intervention was done after 4-5 weeks of treatment. The results of this research single out new prognostic criteria of the tumor radiosensitivity level. Superoxide radicals speed production value before the treatment more than 1,0 nmol/min.·body weight in g. of raw tissue; the low level of the 8-oxoG daily excretion in the urine before the treatment – less than 0,5 nmol/period.·body weight in kg; and the increasing of the 8-oxoG index level in the urine at 50% and more relative to the baseline the day after the beginning of radiotherapy points at the high level of tumor radiosensitivity.
The 8-oxoG excretion level of rectal cancer patients before the treatment in accordance with the degree of pathomorphosis (the mean value, the minimum – the maximum, the trendline).
How to cite this article:
Volodymyr V. Golotyuk, Anatoliy P. Burlaka. Redox-dependent Markers for Response to Neoadjuvant Radiotherapy for Rectal Cancer. Pharma Innovation 2014;3(6):24-27.