Formulation design and evaluation of xyloglucan microsphere of silymarin
Laxmi Bhumarkar, Alka Arkhel, Suman Ramteke
The objective of the present work was to prepare and systematically evaluate in vitro and in vivo performances of xyloglucan microsphere of silymarin. Microspheres were prepared by the emulsification method using glutaraldehyde as a cross-linking agent. Surface morphological characteristics of microspheres investigated using scanning electron microscopy and light microscopy. The drug polymer compatibility, percentage of yield, swelling index, drug entrapment efficiency and in vitro drug release studies were performed and the drug release data was treated with mathematical kinetic models. The pharmacokinetic experiments showed that the area under the curve of silymarin plasma concentration–time profile in rats for standard silymarin was lower than silymarin entrapped xyloglucan microspheres. Tissue distribution studies of xyloglucan microspheres indicated that a significantly increased amount of silymarin was accumulated in the liver. The present study was focused on development of silymarin microspheres by using biodegradable polymers and to study the effect of method of preparation on physical properties, drug release profile and in vivo study of xyloglucan microspheres.
Scanning electron micrographs of xyloglucan microspheres
How to cite this article:
Laxmi Bhumarkar, Alka Arkhel, Suman Ramteke. Formulation design and evaluation of xyloglucan microsphere of silymarin. Pharma Innovation 2014;3(4):92-102.