Immune and inflammatory predictors of survival in patients with severe community-acquired pneumonia
Pertseva T.A., Kireeva T.V., Bielosludtseva K. O*, Volkova S.A.
Questions of survival predicting in patients with severe community-acquired pneumonia (CAP) remain relevant and poorly understood.
The aim of this work was to determine the significance of cellular immunity markers CD4, CD8 and markers of systemic inflammation procalcitonin (PCT) and C-reactive protein (CRP) as a predictor of survival in these patients using of cluster analyze.
According the research revealed that more than half of patients with severe community-acquired pneumonia have violations of cellular immunity of varying severity, the feature of survival predicting of patients with severe CAP is the account of the pathogenetic mechanisms, namely a complex set of immune factors interact with inflammatory markers. The most significant laboratory predictors of the outcome are the individual dynamics of the cell immunity marker CD4 and inflammatory marker PCT.
At a significant reduction of the serum PCT level and an increase of CD4 count during the adequate ABT a favorable outcome of pneumonia can be expected, while the PCT increase and CD4 decrease, on the contrary, are unfavorable for the survival.
How to cite this article:
Pertseva T.A., Kireeva T.V., Bielosludtseva K. O*, Volkova S.A.. Immune and inflammatory predictors of survival in patients with severe community-acquired pneumonia. Pharma Innovation 2014;3(3):21-26.