Association of C-511 polymorphism of interleukin 1β gene with uterine adnexae inflammation in puberty age girls
Larysa Sydorchuk, Kateryna Gumenna, Oksana Andriyets, Andriy Sydorchuk, Oksana Bodnarjuk
The aim of the study was to analyze the association of 511C/T polymorphism of IL-1β gene (rs16944) with specific and nonspecific salpingoophoritis in juvenile girls (12-18 years). The IL-1β 511C/T gene polymorphism was analyzed by means of polymerase chain reaction in 88 patients with salpingoophoritis and 31 healthy individuals. Among patients with nonspecific salpingoophoritis T-allele frequency dominates the CC-genotype by 4.99 times. The presence of T-allele or TT genotype of IL-1β gene increases a predisposition risk for adnexal inflammation, regardless of their specificity, in girls of pubertal age (especially at the age of 15-18) by 1.54-2.58 times [OR=2.34-4.17, OR 95% CI=1.07-12.6 p≤0.032-0.002]. C-allele and CC genotype play a protective role and show the lowest probability of adnexal inflammation, especially nonspecific salpingoophoritis [OR = 0.28-0.43, p≤0.022-0.001]. Thus, T-allele of IL-1β gene C-511T polymorphism is associated with adnexa inflammation in girls at the age of puberty.
How to cite this article:
Larysa Sydorchuk, Kateryna Gumenna, Oksana Andriyets, Andriy Sydorchuk, Oksana Bodnarjuk. Association of C-511 polymorphism of interleukin 1β gene with uterine adnexae inflammation in puberty age girls. Pharma Innovation 2014;3(2):24-32.