Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS RATING: 5.23, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.23 new

Vol. 3, Issue 10 (2014)

Simultaneous UV spectrophotometric estimation of Olmesartane medoxomil and chlorthalidone in tablet dosage form

Author(s):
D. Barot, P. K. Pradhan, G. Patel, S. Shah, H. P. Parmar, S. Dey, U. M. Upadhyay
Abstract:
A simple, rapid and accurate new UV spectroscopic is described for simultaneous estimation of Olmesartan Medoxomil (OLM) and Chlorthalidone (CLT) in synthetic mixture. The method depends on direct determination of OLM at 260 nm and absorption correction method for estimation of CLT at 215 nm. The method is accurate (% recovery 101.81 ± 0.001 and 101.53 ± 0.002, precise in the range 4 - 32 (LOD) and 2.5 – 20 (LOD) μg/ml for OLM and CLT respectively. The developed method was validated as per ICH guideline and the results were found to be satisfactory and successes fully marketed formulation.
Chemical structure of Olmesartan Medoxomil.
Fig.: Chemical structure of Olmesartan Medoxomil.
Pages: 76-80  |  1209 Views  8 Downloads


The Pharma Innovation Journal
How to cite this article:
D. Barot, P. K. Pradhan, G. Patel, S. Shah, H. P. Parmar, S. Dey, U. M. Upadhyay. Simultaneous UV spectrophotometric estimation of Olmesartane medoxomil and chlorthalidone in tablet dosage form. Pharma Innovation 2014;3(10):76-80.
Important Publications Links
The Pharma Innovation Journal

The Pharma Innovation Journal

Call for book chapter
The Pharma Innovation Journal