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Vol. 3, Issue 1 (2014)

Synthesis of 5-R-4-R1-3-alkylthio-1,2,4-triazoles and study influence of their adsorption ability on the results of toxicity and anti-hypoxic activity

Author(s):
Yu. M. Kucheryavyi, A. G. Kaplaushenko, A. S. Korzhova
Abstract:
During our research of biologically active substances we have synthesized series of new 5-R-4-R1-3-alkylthio-1,2,4-triazoles for original drugs creation. 14 new compounds have been synthesized in total. The structure of it has been confirmed by a complex of modern physical and chemical methods of analysis. For these compounds the data of toxicity, anti-hypoxic activity, surface activity and adsorption ability has been set. The obtained results of biological activity have been compared with data of adsorption properties of 1,2,4-triazoles derivatives to establish structure-action regularity.
The dependence of adsorption from the concentration of compounds 9, 12, 14,18
Fig.: The dependence of adsorption from the concentration of compounds 9, 12, 14,18
Pages: 69-73  |  1052 Views  5 Downloads
How to cite this article:
Yu. M. Kucheryavyi, A. G. Kaplaushenko, A. S. Korzhova. Synthesis of 5-R-4-R1-3-alkylthio-1,2,4-triazoles and study influence of their adsorption ability on the results of toxicity and anti-hypoxic activity. Pharma Innovation 2014;3(1):69-73.
The Pharma Innovation Journal