Formulation and evaluation of amlodipine besylate orally disintegrating films
K. Mani Chandrika, T. Praveen kumar, P. Narayana Raju
The objective of this study was to prepare the orally disintegrating films of Amlodipine besylate by solvent casting method using polymers such as HPMC E3, HPMC E6 and natural polymer Pullulan gum. The films were characterized for various physicochemical properties such as thickness measurement, weight variation, % drug content, folding endurance, in vitro disintegration time, in vitro dissolution. The formulation with Pullulan gum, F9 is found to be best formulations. In vivo taste and mouth evaluation were conducted on selected age group of the people having 30-35 years and it was found that the films prepared with Sweetener acesulfame potassium and orange flavor gives excellent taste and mouth feel. The DSC and FTIR study revealed no drug polymer interactions. SEM study showed that films were clear, transparent and had a smooth surface the surface property. The prepared orally disintegrating films have good commercial success.
How to cite this article:
K. Mani Chandrika, T. Praveen kumar, P. Narayana Raju. Formulation and evaluation of amlodipine besylate orally disintegrating films. Pharma Innovation 2014;3(1):23-32.