Hypercapnia Correction in Chronic Obstructive Pulmonary Disease Patients with Sleep-Disordered Breathing
Y. I. Feshchenko, L. O. Iashyna, S. G. Opimakh
This study was performed with the aim to evaluate the possibility of capnometry in efficacy and safety control of CPAP-therapy in chronic obstructive pulmonary disease (COPD) patients with sleep-disordered breathing and hypercapnia. Materials and Methods: For 10 patients with COPD combined with obstructive sleep apnea or obesity hypoventilation syndrome, in whom hypercapnia was observed CPAP-therapy was performed under the control of capnometry. Results: After treatment we observed a statistically significant reduction in CO2 level in the exhaled air of the patients: FECO2 decreased from (4.46 ± 0.13) % to (3.71 ± 0.15) %, FETCO2 from (6.40 ± 0.21) % to (5.63 ± 0.24) %, p < 0.01, which means lower the degree of hypercapnia in patients. Conclusion: Capnometry allow to control efficacy and safety of CPAP-therapy in patients with COPD and hypercapnia with the minimal clinically important difference for FETCO2 is 0.31%.
How to cite this article:
Y. I. Feshchenko, L. O. Iashyna, S. G. Opimakh. Hypercapnia Correction in Chronic Obstructive Pulmonary Disease Patients with Sleep-Disordered Breathing. Pharma Innovation 2014;2(12):61-66.