Vol. 2, Issue 9 (2013)
Effects of leaf decoction from Lophira lanceolata Tiegh. Ex Keay (Ochnaceae) on arterial blood pressure and electrocardiogram in anesthetized rabbits
Kouakou Kouakou Léandre, Bléyéré Nahounou Mathieu, Oussou N’Guessan Jean-Baptiste, Konan Brou André, Amonkan Kouao Augustin, Abo Kouakou Jean Claude, Yapo Angoué Paul, Ehilé Ehouan Etienne
Lophira lanceolata (Ochnaceae) is a plant used in traditional medicine to treat many illnesses such as headaches, dysentery, diarrhoea, cough, abdominal pains and cardiovascular diseases. Ethnobotanical surveys in the centre of Côte d’Ivoire revealed that this plant is employed in the treatment of hypertension by traditional healers. As no or few scientific works were undertaken on this side, the present study was aimed to assess the effects of a decoction of Lophira lanceolata on arterial blood pressure and electrocardiogram in rabbits. The recording of the arterial blood pressure was achieved by a mercury manometer kymograph of Ludwig while the registration of electrocardiogram was implemented by an electrocardiograph (CARDIOFAX ECG-6851K Nihon Kohden, Japan). The decoction of the fresh leaves of Lophira lanceolata (DALLA) induced a dose dependent hypotension in rabbits for doses ranging from 0.5 to 40 mg/kg body weight with an ED50 (effective dose) of 8.67 mg/kg body weight. DALLA significantly decreased the transient hypertension caused by adrenaline at 5.10-3 mg/kg body weight. The hypotension induced by DALLA was significantly attenuated by atropine (a muscarinic cholinoceptor antagonist). On rabbit electrocardiogram, DALLA decreased the amplitudes of P, QRS and T waves, the duration of PQ interval and heart rate. However, the duration of QT interval increased. The phytochemical screening of the extract revealed the presence of sterols and polyterpenes, phenols, flavonoids, catechic tannins, alkaloids and saponins. These results suggested that DALLA contained cholinomimetic substances and also interacted with adrenoceptors. Some of the phytochemical coumpounds such as phenols, flavonoids, catechic tannins and alkaloids which are known for their antihypertensive effects may explain the use of this plant by traditional healers to treat hypertension.
Dose response effect of DALLA on arterial blood pressure of rabbit
How to cite this article:
Kouakou Kouakou Léandre, Bléyéré Nahounou Mathieu, Oussou N’Guessan Jean-Baptiste, Konan Brou André, Amonkan Kouao Augustin, Abo Kouakou Jean Claude, Yapo Angoué Paul, Ehilé Ehouan Etienne. Effects of leaf decoction from Lophira lanceolata Tiegh. Ex Keay (Ochnaceae) on arterial blood pressure and electrocardiogram in anesthetized rabbits. Pharma Innovation 2013;2(9):66-73.