Vol. 2, Issue 8 (2013)

Author(s):
Anna M. Dutchak, Olga B. Synoverska

Abstract:
The paper presents the results of our investigation of the cytokine status features and contents of soluble form of vascular cellular adhesion molecules in children with atopic dermatitis and atopic dermatitis on the background of undifferentiated connective tissue dysplasia. In atopic dermatitis the content of interleukin-2, interleukin-4, and soluble form of vascular cellular adhesion molecules has been proved to increase by contrast to healthy children. Immunoregulation indices have been noted to increase with severity of atopic dermatitis rise. Analysis of intercorrelation relationships between interleukin-2, interleukin-4, and soluble form of vascular cellular adhesion molecules in the system of cytokines demonstrated that they are in an intricate correlation between themselves and with IgE, and these relationships’ intensity and direction depended upon the severity of atopic dermatitis. Concomitant connective tissue dysplasia causes more significant immunoregulation indices deviations in case of severe course of atopic dermatitis.