Vol. 2, Issue 7 (2013)

Author(s):
Galyna Kuryliv

Abstract:
Plasma concentrations  of cytokins TGF-β1, IL-10, TNF-α in patient with heart failure on the basis of coronary heart disease and myocardial infarction according to the type of left ventricular dysfunction were studied. The aim of research was to improve treatment of chronic heart failure patients by regulating the levels of cytokins  by adding to basic therapy medicines Imunofan and Metamax. It was  found the  increased levels of  TGF-β1, TNF-α, IL-10 in all patients. The level of TGF-β1 in patients with preserved left ventricular ejection fraction and systolic dysfunction of the left ventricle increased after treatment.  We found the  increased level of  IL-10 in patients. After treatment a clear decrease of IL-10 is typical for patients with preserved ejection fraction of left ventricular, whereas in patients with systolic dysfunction of  left ventricular IL-10 levels remain more constant. Observed increasing of TNF-α, which decreased after treatment in all groups, but most definitely  in patients with preserved ejection fraction of left ventricular.