Formulation and Development of Floating and Mucoadhesive Microspheres of Clarithromycin
Sanjeev Kumar*, Tara Chand
The basic objective of this comparative study between gastro retentive floating microspheres and mucoadhesive microspheres of drugs Clarithromycin. Floating microspheres and mucoadhesive microspheres loaded with Clarithromycin in their outer polymer shells were prepared by emulsification solvent evaporation method. Using different grades of hydroxyl propyl methylcellulose (HPMC) such as HPMC K15M, HPMC K100M, carbopol 934, carbopol 940 and ethyl cellulose (EC). The prepared microspheres were characterized by polymer compatibility, percentage yield, buoyancy percentage, drug entrapment efficiency and in vitro drug release. An optimized formulation investigated for morphology and particle size analysis by scanning electron microscopy. Clarithromycin has low bioavailability i.e. 50-60% due to its first pass metabolism. Floating and mucoadhesive microspheres have been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug.
How to cite this article:
Sanjeev Kumar*, Tara Chand. Formulation and Development of Floating and Mucoadhesive Microspheres of Clarithromycin. Pharma Innovation 2013;2(5):19-26.