Relationship Between Hemodynamic and Cytokines Disorders Depending of Endogenous Insulin Levels in Hypertensives with Heart Failure
Oleg M. Sheremeta
The study of relationship between blood pressure (BP) disorders and cytokines activation in 114 hypertensives with HF class II-III NYHA (45 male, 69 female), aged 59±12 years, and different endogenous insulin (EI) levels was performed. We revealed the increasing of ABPM parameters depending to plasma EI levels and severe class of HF. Increasing of proinflamatory TNF-α in hypertensives with normal EI levels is more typically for HF class III NYHA. Anti-inflammatory cytokine IL-10 levels are increased in the early HF stages. The patients with 2hr postloading hyperinsulinemia are characterized by a significant increasing of proinflammatory and anti-inflammatory cytokines activity depending to HF progression compared with patients with normal EI levels. The highest plasma TNF-α, IL-6 and IL-10 levels and their ratios were revealed in patient with fasting hyperinsulinemia and HF class III.
How to cite this article:
Oleg M. Sheremeta. Relationship Between Hemodynamic and Cytokines Disorders Depending of Endogenous Insulin Levels in Hypertensives with Heart Failure. Pharma Innovation 2013;2(5):81-85.