Vol. 2, Issue 4 (2013)

Author(s):
Sushma Dev, Dr Ramesh Bodla

Abstract:
A series of 3-benzoylsulfanyl derivatives of 4-methyl-1,2,4-triazole were synthesized by acylation of starting triazole-3-thiol with appropriately substituted benzoyl halide. All members of the set were evaluated for in vitro antimicobacterial activity againstPsuedomonas aerogenosa, Escherichia coli, Bacillus subtilis, Bacillus pumitis and antifungal acivity against A. niger, C. albicans. The activities were expressed as the minimum inhibitory concentration. The compound exhibited only a moderate or slight antimycobacterial activity. The structures of the newly synthesized compounds were characterized by IR, 1H NMR and elemental analysis.