Vol. 2, Issue 3 (2013)

Author(s):
Zia-ur-Rahman, Imran khan, Alija Baig, Ali Raza Quraishi, Fazl e Zahir

Abstract:
Paracetamol (acetaminophen) is an OTC drug available also in dosage form of compressed tablets in almost all countries, being extensively used as antipyretic and general analgesic. In KPK Pakistan numbers of brands are available manufactured in local industrial zones. Here in this laboratory research we have tried to follow the simple approaches i.e. the British Pharmacopoeia and USP and other standard book’s standards and procedures to evaluate the quality parameters of different brands (3 brands A, B and C), by selecting samples of different batches (3 batches of each), manufactured in industrial zones of KPK Pakistan (by 3 different manufacturers). Types of quality tests performed are weight variation, disintegration time, dissolution, hardness and friability. Finally the results evaluate no significant deviations from the compendial standards and specifications, and we got the aim of our study that these brands of local manufacturers in KPK are safe enough and could be used to achieve the desired therapeutic effect which has been discussed in paper.