Vol. 2, Issue 2 (2013)

Author(s):
Jimidi.Bhaskar, Malothu.Jagadish Naik

Abstract:
Clopidogrel bisulphate has been the most widely used as antithrombotic. Clopidogrel has greater solubility in acidic pH and it is absorbed through gastrointestinal region. The aim of the present research work was to develop the mucoadhesive micro-spheres containing clopidogrel. The micro-spheres were prepared by ionotrophic gelation method. The microcapsules were prepared with HPMC K4M, Xanthan gum and pectin along with sodium alginate. The prepared micro-spheres were characterized for various physicochemical properties such as , particle size distribution, entrapment efficiency, in vitrodissolution, in vivo radiographic study, DSC, FTIR and SEM study. In vitro drug release study showed that the drug release was extended up to 14 hours and the drug release was mainly depend on the polymer ratio and polymer concentration. In vivo radiographic study revealed that the prepared micro-spheres retained in the stomach for more than 6 hours. DSC and FTIR study showed no drug polymer interaction. SEM study showed the spherical and porous nature of the prepared micro-spheres.