Vol. 1, Issue 8 (2012)

Author(s):
A. Badoni, A. Ojha, G. Gnanarajan, P. Kothiyal

Abstract:
GRDDs are an approach to prolong gastric residence time, there by targeting site-specific drug release in the upper GIT for local or systemic effect. Gastro retentive dosage forms (GRDFs) are being used from a very long time to improve therapy with several important drugs. GRDFs greatly improves the pharmacotherapy of stomach by releasing the drug locally and thus results into high concentration of drug at the gastric mucosa which can be sustained over a longer duration of time. GRDFs enable prolonged and continuous release of the drug to the upper part of Gastro intestinal tract (GIT) and this significantly extend the duration of drug release and improve bioavailability of drugs that have narrow therapeutic window, by this way they prolong dosing interval and increase compliance of the patient. The purpose of this paper is to briefly describe the gastro retentive drug delivery (GRDD), factors related to GRDD, its advantages disadvantages, and emphasis is given over its significance over conventional form of drug deliveries.