Vol. 1, Issue 8 (2012)

Author(s):
Soniya Madaan*, Atul Kumar Gupta, Vipin Sardana

Abstract:
The aim of this study was to mask the bitter taste of Atenolol along with solubility enhancement by solid dispersion system. Solid dispersions were prepared by the solvent evaporation method using Î²-cyclodextrin. The solid dispersion of atenolol with Î²-cyclodextrin was evaluated by Differential scanning colorimeter (DSC), Scanning electron microscopy (SEM). The taste masking property of solid dispersions in different ratio combination of Atenolol with Î²-cyclodextrin was evaluated on human volunteers. The influence of different ratio of carrier on solubility of drug was also evaluated. Solid dispersion at ratio 1:3 w/w completely masks the bitterness of Atenolol. The solubility and dissolution rate of Atenolol was significantly increased by solid dispersion as well as by their physical mixture.