Vol. 1, Issue 5 (2012)

Author(s):
G. Praveen

Abstract:
The buccoadhesive tablets of Losartan Potassium were developed to prolong the drug  release and to improve the bioavailability of the drug by avoidance of the hepatic first pass metabolism during the treatment of chronic hypertension.  The formulations were tested for weight variation, hardness, friability, content uniformity, swelling index, bio- adhesive time  and the drug release rate. The Carbopol 934P was used as the bio-adhesive polymer, HPMC K4M and HPMC K15 M was added as a matrix former. The ethyl cellulose was used as the backing layer. The optimised formulation containing Carbopol 934P  and HPMC K4M (in the ratio of 1:1) showed the surface pH value in the range of 6 to 7 and 94.49%  of drug was released in 10hours and showed the  best bio- adhesive time up to 11 hours.