Vol. 1, Issue 3 (2012)

Author(s):
Ashish Y Pawar, Deelip V Derle

Abstract:
The purpose of this investigation was to develop and characterize a biodegradable implants containing Ciprofloxacin hydrochloride (HCl) for the localized treatment of osteomyelitis. Chitosan is widely investigated biodegradable polymer and has reactive hydroxyl groups that can be modified chemically for various biomedical and pharmaceutical applications. In this study the reactive hydroxyl groups of Chitosan were modified using epichlorohydrin & crosslinked Chitosan matrices were used as carrier to formulate different Ciprofloxacin implants. The developed formulations were evaluated for different In vitro parameters. The formulations having 40% drug loading (EC4) was found to be optimum in terms of various evaluation parameters. The present work concluded that, the concentration of crosslinked chitosan plays crucial role in retardation of drug release from biodegradable implantable matrices.