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Vol. 1, Issue 10 (2012)

Quantitative CT assessment of pancreatic fat in type 2 diabetes mellitus

Dr. Rampam Sri Hari Narayana
Objective: To characterize the pancreatic fat deposition (PFD) in patients with type 2 diabetes mellitus (T2DM) by quantitative computed tomography (QCT) and investigate the relationship between PFD and clinical metabolic parameters and islet function.
Materials and Methods: A total of 150 patients with T2DM and 93 age-matched healthy subjects underwent QCT to quantify PFD were included. PFD and various biochemical parameters were correlated by statistical methods and multiple stepwise linear regression modeling.
Results: PFD measured by QCT in the T2DM group was statistically higher than that in the healthy control group, and the pancreatic CT value was statistically lower than that in the control group. The QCT measured PFD was negatively correlated with the pancreatic CT values (P < 0.001), and positively correlated with triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), visceral fat area (VAT) and insulin resistance index (HOMA-IR) (P < 0.05) in the T2DM patients. Multiple stepwise linear regression analysis identified PFD as the dependent variable factor for T2DM.
Conclusion: This study suggests QCT as a reliable technique in measuring PFD in T2DM. High PFD is positively correlated with the degree of insulin resistance and may play an important role in islet cell dysfunction in T2DM.
Pages: 94-101  |  42 Views  25 Downloads

The Pharma Innovation Journal
How to cite this article:
Dr. Rampam Sri Hari Narayana. Quantitative CT assessment of pancreatic fat in type 2 diabetes mellitus. Pharma Innovation 2012;1(10):94-101.

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