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Vol. 1, Issue 10 (2012)

Criteria for the non-invasive prediction of large esophageal varices based on clinical, laboratory, and imaging data

Author(s):
Dr. Ananth Gopalrao Kulkarni, Dr. Pagadala Koteswar
Abstract:
Introduction: A portal pressure gradient over 5-10 mm Hg is indicative of portal hypertension, which is a defining feature of cirrhosis. Varices form in individuals with portal hypertension when the flow of blood through the portal circulation is redirected by portosystemic collaterals.
Methods: This prospective study included all consecutive newly diagnosed patients at our tertiary referral center, Department of Paediatrics, D.D. Medical College and Hospital, Thiruvallur, Tamil Nadu, India, between August 2011 and July 2012, with or without gastrointestinal bleeding. Informed permission was signed by patients before to enrollment in the trial.
Results: In all, eighty people took part in the study. The population's age range spans from 15 to 70 years old, with a median age of 45. There were 2.11 male patients for every female patient. The patients were sixty-two men. Ninety days was the average duration of symptoms (range, 10-230 days). Of the patients, 43 exhibited pedal edoema and 50 had evident ascites.
Conclusion: If this method is proven to be effective, it would obviate the necessity for costly and invasive procedures such as gastrointestinal endoscopy. Additionally, it would enable the utilization of beta-adrenergic antagonists as preventive measures against primary variceal hemorrhage in patients suffering from liver cirrhosis.
Pages: 88-93  |  36 Views  22 Downloads


The Pharma Innovation Journal
How to cite this article:
Dr. Ananth Gopalrao Kulkarni, Dr. Pagadala Koteswar. Criteria for the non-invasive prediction of large esophageal varices based on clinical, laboratory, and imaging data. Pharma Innovation 2012;1(10):88-93.

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