Vol. 7, Issue 9 (2018)

Author(s):
Neha Sikri and Sunita Dalal

Abstract:
The plants of Acanthaceae family traditionally been used as significant source of therapeutic preparation. For the treatment of various diseases like gastrointestinal tract & hepato-protective disorders, inflammatory diseases, fevers and snake poisoning as well. In the present study we have examined the antioxidant and urease inhibitory potential of aqueous and methanol extracts of leaves of two plants of Acanthaceae family viz. Andrographis paniculata and Justicia adhatoda. Different analysis revealed that the aqueous extract of Andrographis paniculata leaves not only exhibited significant antioxidant potential in different assays performed but also exhibited considerable urease inhibitory potential(45.32%) as compared to the standard inhibitor, thiourea exhibited percent inhibition 71.47%. Quantitative evaluation of phytochemicals also revealed that the aqueous extracts of Andrographis paniculata leaves possessed the high flavonoid and phenolic content (75.67 mgGAE/gm and 85.66 mgGAE/gm) respectively. This study validates that Andrographis paniculata leaves, part of various therapeutic preparations for many years, can be used for the treatment of gastrointestinal disorders, stomach related disorders and other urease related infections as well.