Vol. 7, Issue 8 (2018)

Author(s):
Komal Pangavhane and Ravindranath Saudagar

Abstract:
The present work aims towards the development of controlled release formulation of water soluble drug Vildagliptin based on osmotic technology by using controlled porosity approach. Vildagliptin is anti-diabetic drug with short half-life, makes the development of controlled release dosage forms extremely advantageous. A present work comprises a drug Vildagliptin, NaCl, HPMC, Magnesium Stearate, Lactose, PVP K30, Talc, Cellulose acetate, PEG 400. NaCl was used as an osmogent and HPMC K100M was used as a release retardant. Cellulose acetate was used as the semipermeable membrane and PEG 400 was used as pore forming agent. Optimization was done using 3² factorial design considering two independent variable at three levels. Optimized formulation (F8) exhibited zero order kinetics with a drug release of 98.84% in 24hrs. Scanning electron microscope study showed the formulation of pores in membrane. It was concluded that release of Vildagliptin was significantly controlled from controlled porosity osmotic drug delivery system.