Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 7, Issue 6 (2018)

Comparative in vitro dissolution test and other physicochemical parameters of some commercially available metformin HCl brands in Bangladesh

Author(s):
Israt Jahan Prithi, Sayeeda Fahmee Chowdhury and Sayeeda Tasneem Chowdhury
Abstract:
Metformin is an oral anti diabetic medicine that helps control blood sugar levels used together with diet and exercise in adults with type 2 diabetes mellitus. The aim of this work was to evaluate the quality parameters of three marketed brands of Metformin HCl 500 mg available in Bangladesh and to do a comparative study of these brands. In weight variation test highest positive and negative percent deviations were +2.491 and -3.361 which were within the limits. Average diameter, thickness, hardness and friability were found within the limits. Potency of brand A, B and C were 100.42%, 100.06% and 104.6%, respectively. All the samples had shown satisfactory percent drug release (>80%) within 30 minutes. Dissolution studies were performed using USP type II apparatus at a temperature of 37±0.5ºc, 100 RPM, 900 ml phosphate buffer (pH 6.8) and samples were estimated spectrophotometrically at 231 nm. After sixty minutes in-vitro dissolution study of sample A, B and C, an average % drug release of 98.96%, 100.165% and 100.77% were found, respectively. All the brands of Metformin HCl successfully met the quality parameters.
Pages: 05-08  |  414 Views  41 Downloads
How to cite this article:
Israt Jahan Prithi, Sayeeda Fahmee Chowdhury and Sayeeda Tasneem Chowdhury. Comparative in vitro dissolution test and other physicochemical parameters of some commercially available metformin HCl brands in Bangladesh. The Pharma Innovation Journal. 2018; 7(6): 05-08.
Journals List Click Here Research Journals Research Journals
Call for book chapter