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Vol. 7, Issue 6 (2018)

Comparative in vitro dissolution test and other physicochemical parameters of some commercially available metformin HCl brands in Bangladesh

Author(s):
Israt Jahan Prithi, Sayeeda Fahmee Chowdhury and Sayeeda Tasneem Chowdhury
Abstract:
Metformin is an oral anti diabetic medicine that helps control blood sugar levels used together with diet and exercise in adults with type 2 diabetes mellitus. The aim of this work was to evaluate the quality parameters of three marketed brands of Metformin HCl 500 mg available in Bangladesh and to do a comparative study of these brands. In weight variation test highest positive and negative percent deviations were +2.491 and -3.361 which were within the limits. Average diameter, thickness, hardness and friability were found within the limits. Potency of brand A, B and C were 100.42%, 100.06% and 104.6%, respectively. All the samples had shown satisfactory percent drug release (>80%) within 30 minutes. Dissolution studies were performed using USP type II apparatus at a temperature of 37±0.5ºc, 100 RPM, 900 ml phosphate buffer (pH 6.8) and samples were estimated spectrophotometrically at 231 nm. After sixty minutes in-vitro dissolution study of sample A, B and C, an average % drug release of 98.96%, 100.165% and 100.77% were found, respectively. All the brands of Metformin HCl successfully met the quality parameters.
Pages: 05-08  |  314 Views  39 Downloads
How to cite this article:
Israt Jahan Prithi, Sayeeda Fahmee Chowdhury and Sayeeda Tasneem Chowdhury. Comparative in vitro dissolution test and other physicochemical parameters of some commercially available metformin HCl brands in Bangladesh. 2018; 7(6): 05-08.
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