Vol. 7, Issue 4 (2018)

Author(s):
OS Lynda, LS Fira and PH Lykhatskyi

Abstract:
Recently, the attention has been focused on the problem of the search and creation of herbal medical products having hepatoprotective properties. This interest has grown due to the wide spectrum of pharmacological effects of phytomedicine and the minimum number of side effects in the case of long-term use. Hosta lancifolia is not an officially registered healing plant, but is cultivated throughout the world due to its decorative properties. The plant contains a number of biologically active substances, including flavonoids and hydroxycinnamic acids. The purpose of this research work was to find out the effect of Hosta lancifolia dry extract on the biliary function of rat liver damaged with tetrachlormethane (CCl4). Experiments with of bile duct system and bile-forming liver function were performed on the white mongrel male rats with induced acute tetrachloromethane hepatitis. The affected animals were fed with a dry extract of Hosta lancifolia at a dose of 100 mg / kg body weight of the animal. A choleretic herbal remedy “Flamin” was used as a comparison medication which animals received at a dose of 250 mg / kg. The biliary and bile-forming liver function was evaluated at the 4th, 7th and 14th days of the experiment. All the rules of the Convention on the protection of vertebrate animals were observed during the experiments. The obtained results showed that the use of dry extract from Hosta lancifolia led to the normalization of biliary function of the liver, indicating an increase in the volume of bile and the rate of bile formation by animals affected with tetrachloromethane in all three terms of the experiment. Hosta lancifolia extract demonstrated a visible positive effect on bile liver function. There was a probable decrease in the concentration of bile acids and the bilirubinconcentrationlevelafter its use in rat blood serum of animals affected with tetrachloromethane.