Vol. 7, Issue 3 (2018)

Author(s):
Kouassi Kousso Brigitte, Adjambri Adia Euserbe, Kone Mama, Sawadogo Duni and Yapo Angoué Paul

Abstract:
Sacoglottis gabonensis is a medicinal plant used in the treatment of Buruli ulcer in Côte d’Ivoire. The stem bark aqueous extract of this plant has a lethal dose 50% (LD₅₀) higher than 5000 mg/kg body weight (b.w.) in mice and is nontoxic for rats when administered subacutely. To assess the subchronic toxicity of this extract, it is administered, by oral route, daily for 90 days to rats at the doses of 3.5; 35 and 350 mg/kg b.w. while the control group rats were gavaged with distilled water. The amounts of food and water consumed by rats were monitored every day. The rats were weighed once per week. Blood samples and blood smear were taken at the end of every month. Results showed that S. gabonensis extract (3.5 and 35 mg/kg b.w.) did not influence anthropometric parameters while a significant decrease of these parameters was observed in the rats treated with the dose of 350 mg/kg b.w. of this extract. Administration of the extract did not alter most of the hematological parameters. However, all the doses of S. gabonensis extract increased thrombocyte levels and neutropenia at 350 mg/kg b.w. only. The blood smear didn’t show any abnormality in erythrocyte cells’ size, shape and staining of the rats treated with S. gabonensis stem back extract. In sum, this study revealed that the aqueous extract of S. gabonensis stem bark is nontoxic on blood cells, at a therapeutic dose 3.5 mg/kg b. w. for 90 days-administration in rats.