Vol. 6, Issue 3 (2017)
Allele frequency of CYP2C19 (*1 and*3) gene polymorphism in Palestinian population
Lamia'a Sobhi Saqer and Lamia Fesal Abumarzoq
Human cytochrome P450, particularly CYP2C19 play an important role in drug metabolism. The polymorphisms of this enzyme give rise to change variability in drug excretion rates and function. In this study we determined genotypes of CYP2C19 (*1 and *3) in Palestinian population to compare allele frequencies with other ethnic groups finding. CYP2C19 (*1/*3) allelic variants were determined in 213 unrelated healthy Palestinian volunteers by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assays. Three subjects (1.4%) were homozygous for CYP2C19*3, 88 (41.3%) were homozygous for wild type allele (CYP2C19*1/*1) while 122 (57.3%) individuals were heterozygous for variant allele (CYP2C19*1/*3). The frequency of CYP2C19*1 and CYP2C19*3 alleles were 0.692 and 0.308 respectively. In addition, based on our data, the frequencies of EM and PM were 98.6% and 1.4% respectively. Further studies are required to evaluate the metabolic and clinical significance of other CYP2C19 alleles, in the Palestinian population.
How to cite this article:
Lamia'a Sobhi Saqer and Lamia Fesal Abumarzoq. . The Pharma Innovation Journal. 2017; 6(3): 80-83.