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NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
NAAS Rating: 5.03 new
Vol. 6, Issue 3 (2017)

Dynamics of features of heart rate variability with application of alpha-lipoic acid in patients with type 2 diabetes mellitus who have had myocardial infarction

N Altunina and V Lizogub
The article presents the dynamics of heart rate variability (HRV) features of 59 patients with type 2 diabetes mellitus (DM) who have had non-Q-myocardial infarction (non-Q-MI) under the influence of 4-month treatment of alfa-lipoic acid (ALA). Treatment showed a significant increase in high frequency activity HF (p<0.01), HFnorm (p<0.05) in the daytime with an increase in its contribution to the total spectral power – HF% (p<0.05). Besides, it was recorded a decrease in percentage contribution of low-frequency LFnorm% (p<0.001) and the growth of high-frequency HFnorm% activity (p<0.001) in the autonomic regulation of heart rate during the active period of time, which is reflected in sympathovagal interaction index LF/HF (p<0.001). Thus, the 4-month use of ALA in addition to the basic therapy of patients with type 2 DM who had non-Q-MI, causes positive effect on HRV, that includes the increase in the tone of the parasympathetic link of autonomic nervous system and normalizing of sympathovagal interaction in daytime.
Pages: 23-26  |  781 Views  21 Downloads
How to cite this article:
N Altunina and V Lizogub. . The Pharma Innovation Journal. 2017; 6(3): 23-26.
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