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Vol. 6, Issue 2 (2017)

In-silico evaluation of druggability prioritization targets of Escherichia coli in Gallus gallus

Author(s):
Usharani K, Gopala Reddy A, Vijay Kumar M, Anil Kumar B, Bichamma V, Madhuri D and Kumarasamy P
Abstract:
An experimental study was conducted to evaluate the druggability prioritization targets of E. coli in Gallus gallus. Total proteome of pathogen Vs host comparison was done using comparative genomics followed by protein docking of the target proteins of the pathogen and drug target identification and then calculation of drug prioritization parameters for therapeutic targets. 4,288 proteins of E. coli were compared with 24068 proteins of Gallus gallus using BLASTP analysis. The docking results showed positive ligand poses for proteins 1s7d posed with ligands benzocaine, benzyl penicillin, brimonidine, clofibrate, and phenoxy methyl penicillin, 1sz2 posed with ligands benzyl penicillin, bezafibrate, brimonidine, chlorambucil, ibuprofen, phenoxy methyl penicillin, chlorambucil, tolbutamide and tolnaftate, protein 2azo posed with ligands amsacrine, benzocaine, benzyl penicillin, bezafibrate, brimonidine, chlorambucil, ibuprofen, phenoxymethylpenicillin, chlorambucil, sulfanilamide, tolbutamide, tolnaftate and acetaminophen, Protein 2f1f posed with ligand sulfanilamide, Protein 2glt posed with ligands benzocaine, brimonidine, sulfanilamide and acetaminophen, protein 2yva posed with ligands amsacrine, benzocaine, bezafibrate, brimonidine, chlorambucil and ibuprofen, protein 3hi2 posed with ligands benzocaine, brimonidine, sulfanilamide and tolnaftate. protein 1dkl posed with ligands amsacrine, bezafibrate, tolbutamide and tolnaftate, protein 1pho posed with ligands amsacrine, benzocaine, benzyl penicillin, bezafibrate, brimonidine, pirbuterol, ibuprofen, phenoxymethylpenicillin, chlorambucil, sulfanilamide, tolbutamide, tolnaftate and acetaminophen.
The results of the study revealed potential drug targets for developing novel molecules against E. coli viz Gallus gallus.
Pages: 48-52  |  574 Views  17 Downloads
How to cite this article:
Usharani K, Gopala Reddy A, Vijay Kumar M, Anil Kumar B, Bichamma V, Madhuri D and Kumarasamy P. In-silico evaluation of druggability prioritization targets of Escherichia coli in Gallus gallus. 2017; 6(2): 48-52.
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