Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 6, Issue 11 (2017)

Formulation, development and evaluation of antiulcerative drug for colon targeting by extrusion spheronization technique

Author(s):
Deepak Rajak, Akanksha Garud, Mukul Tailang and Navneet Garud
Abstract:
The purpose of study was development of mesalamine colon targeted multiple unit particulate system (Mups). Mesalamine pellets were prepared by extrusion-spheronization process by using microcrystalline cellulose (MCCPH101), povidone K90 and magnesium stearate. The pellets were then coated with ethylcellulose (10 cps 10% w/w) and sodium CMC as retardant. The coated pellets were compressed to form Mups tablet which were subjected for evaluation of various parameters such as bulk density, tapped density, compressibility index, hausner’s ratio, friability, hardness, average weight and in-vitro dissolution study. The best formulation (F4) was found to be within the acceptable limits with hausner’s ratio (1.162-1.327), compressibilty index (20.45-23.51%), average weight range (570-592mg), hardness (140-160 kg/cm2), friability (0.2-0.18%) and thickness (4.10-4.30 mm). The results of in vitro release data indicated that the optimized formulation (F4) showed 100% drug release in 8 h in phosphate buffer (pH 7.2) dissolution medium. A 22 factorial design of experiment was applied by Minitab 17 software in which two factors were taken and evaluated at two levels and experimental trials were performed for all four possible combinations.
Pages: 102-108  |  515 Views  18 Downloads
How to cite this article:
Deepak Rajak, Akanksha Garud, Mukul Tailang and Navneet Garud. Formulation, development and evaluation of antiulcerative drug for colon targeting by extrusion spheronization technique. 2017; 6(11): 102-108.
Journals List Click Here Research Journals Research Journals
Call for book chapter