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Vol. 5, Issue 9 (2016)

Preformulation and characterization studies of aceclofenac active ingredient

Author(s):
Shivani Kala and Divya Juyal
Abstract:
Aceclofenac is a potent analgesic, anti-pyretic and anti-inflammatory agent used in the management of moderate-to-severe pain and in rheumatoid disorder, rheumatoid arthritis and ankylosing spondylitis. Almost all drugs are marketed as tablets, capsules or both. The current aim of the study was to systematically investigate some of the important physicochemical properties of Aceclofenac. Before the development of any dosage form, it is essential to find some fundamental physical and chemical properties of the drug molecule and other divided properties of the drug powder are determined. It helps to decide many of the approaches in formation and development. Thus before selection of excipients, the Preformulation study of any API should be completed for any successful formulation. Preformulation Studies like solubility, pKa, dissolution, melting point, stability in solid state; bulk density, flow properties, were investigated and reported.
Pages: 110-119  |  547 Views  14 Downloads
How to cite this article:
Shivani Kala and Divya Juyal. Preformulation and characterization studies of aceclofenac active ingredient. 2016; 5(9): 110-119.
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