Vol. 5, Issue 7 (2016)

Author(s):
NI Ruschak, VO Zubkov and IS Gritsenko

Abstract:
To extend the molecular diversity of the derivatives of 3-alkyl carboxylic acids of quinolin-4-ones were synthesized a series of new amides 3-(2-methyl-4-oxo-1,4-dihydroquinoline-3-yl) propanoic acids. The final compounds were obtained by several ways. When acids were activated by standard activators, the highest yield of amide was observed by using SOCl₂. Direct aminolysis of esters of 3-(2-methyl-4-oxo-1,4-dihydroquinoline-3-yl) propanoic acids can be realized when their structures have electron withdrawing group in the α- position alkylcarbonyl chain.