Toll Free Helpline (India): 1800 1234 070

Rest of World: +91-9810852116

NAAS Rating: 5.03, Impact Factor: RJIF 5.98 | Free Publication Certificate
updates
NAAS Rating: 5.03 new
Vol. 5, Issue 3 (2016)

Peculiarities of the expression Р16ink4a under cervical intraepithelial neoplasia in women with reproductive disorders

Author(s):
Kindrativ EO
Abstract:
We conducted comprehensive clinic-morphological study of 250 women with cervical intraepithelial neoplasia (CIN) with reproductive function disorders, of which in 157 (62, 8%) female patients was identified DNA of human papilloma virus (HPV) of high carcinogenic risk (HCR). We established the presence of HPV DNA in 62 female patients (56, 4 %) – under mild CIN, in 53 (61, 2%) – under moderate CIN, and 42 (77, 7%) – under sever CIN.
The obtained results of immunohistochemical study indicate that the р16ink4a marker can be used as an additional criterion for the diagnosis of cervical intraepithelial neoplasia associated with papilloma viral infection and for the determination of the dysplastic process degree. Use of р16ink4a allows assessing the potential of dysplasia in relation to the development of cervical cancer and, consequently, to choose an adequate therapeutic tactics of this disease in women with infertility.
Pages: 28-31  |  684 Views  15 Downloads
How to cite this article:
Kindrativ EO. Peculiarities of the expression Р16ink4a under cervical intraepithelial neoplasia in women with reproductive disorders. 2016; 5(3): 28-31.
Journals List Click Here Research Journals Research Journals
Call for book chapter