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Vol. 5, Issue 3 (2016)

Solid as solvent- Novel spectrophotometric analytical method to estimate indomethacin in capsule dosage form using solids (Eutectic liquid of phenol and metformin hydrochloride) as solubilizing agents (Mixed solvency concept)

Author(s):
RK Maheshwari, Toshika Jain, Rohit Adhav, Priyanka Vaswani
Abstract:
The present investigation illustrates the application of mixed solvency concept which states that each and everything present on earth has got solvent character. Authors have tried to show that solid can also be employed as solvent for spectrophotometric analysis of drugs precluding the use of organic solvents. Phenol crystals and Metformin hydrochloride powder were triturated in 4:1 ratio to obtain the eutectic liquid PMHCl 41. There was nice solubility of Indomethacin in PMHCl 41 (more than 200 mg/ml) as compared to the solubility of Indomethacin in distilled water (0.36 mg/ml). In the present research, PMHCl 41 was employed to solubilize the drug (Indomethacin) from capsule powder precluding the use of organic solvent. Phenol, Metformin Hydrochloride and capsule excipients do not interfere in the spectrophotometric analysis at 320 nm. The accuracy, reproducibility and the precision of the method were confirmed by recovery studies and statistical data.
Pages: 24-25  |  763 Views  18 Downloads
How to cite this article:
RK Maheshwari, Toshika Jain, Rohit Adhav, Priyanka Vaswani. Solid as solvent- Novel spectrophotometric analytical method to estimate indomethacin in capsule dosage form using solids (Eutectic liquid of phenol and metformin hydrochloride) as solubilizing agents (Mixed solvency concept). 2016; 5(3): 24-25.
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