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Vol. 5, Issue 10 (2016)

Study of hypoglycemic effect of corosolic acid & its comparative evaluation with standard drug glibenclamide in alloxan induced diabetes in female albino mice

Author(s):
Thakur Rohit Singh, Dr. Jamuna Rani, Dr. TS Hemlatha and Dr. Jyothsna
Abstract:
Background: Diabetes mellitus, commonly referred to as diabetes, is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period. The discovery of insulin and its crystallization has revolutionized the therapeutic goal for diabetic mellitus. The chief drawback of insulin is it must be given by injection. Orally active drugs have always been in searched. Many studies have been proved the hypoglycemic effect of corosolic acid in animals. But thorough evaluation of hypoglycemic effect of corosolic acid with standard hypoglycemic drugs have to be proved. Hence the present study aims in evaluating the hypoglycemic effect of corosolic acid in comparision with standard drug glibenclamide. Results: The results were expressed as mean ± S.D. Statistical difference was tested by using students t-test. A difference in the mean P value <0.05 was considered as significant. Corosolic acid produces consistent hypoglycemic effect at the end of 4th week in comparision with standard drug glibenclamide with extremely significant P value (P<0.01). Mean percentage FBS reduction with corosolic acid in comparision with control group was 18% with extremely significant P value (<0.01)at the end of 4 weeks treatment and glibenclamide produced mean percentage FBS reduction of 31% with extremely significant P value (P<0.01)at the end of 4th week in comparsion with control group. Conclusion: corosolic acid has produced marked hypoglycemia in comparision with standard drug glibenclamide at the end of 4th week.
Pages: 56-59  |  605 Views  20 Downloads
How to cite this article:
Thakur Rohit Singh, Dr. Jamuna Rani, Dr. TS Hemlatha and Dr. Jyothsna. Study of hypoglycemic effect of corosolic acid & its comparative evaluation with standard drug glibenclamide in alloxan induced diabetes in female albino mice. The Pharma Innovation Journal. 2016; 5(10): 56-59.
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