Vol. 4, Issue 2 (2015)
Role of Aloe vera extract in prevention of cadmium induced histoarchitecture changes of lymph node in albino rat
Shikha Dwivedi, Aditya Kumar Gupta
The present study focused on the role of aloevera extract in prevention of cadmium induced pathogenicity in lymphnode of albino rat. Healthy and two month old rats of both sexes were divided into four groups. Rats of I group were given 500 µg cadmium chloride per Kg body weight in drinking water for 30 days. Rats of II group were given extract of Aloe leaves 2 ml per day for 30 days Rats of III group were treated with 500 µm/kg body weight of cadmium chloride along with 2 ml of Aloe extract. Rats of fourth group served as control. Chronic exposure of cadmium chloride produced marked histological alteration in lymph node both at cellular and subcellular levels. Light microscopic study revealed a number of histopathological changes in lymph node of rats of I group. There was extensive degeneration of cells in the cortical and paracortical regions of lymph node that resulted into the reduction in size in cadmium treated rats. At subcelluar level, ultrastructural changes were swelling of mitochondria, increase in the number of free ribosomes due to detachment from RER, and nuclear fragmentation in most of the lymphocytes. Lymph node of rats given with aloevera extract only showed better histological details in comparison of rats of control group.
How to cite this article:
Shikha Dwivedi, Aditya Kumar Gupta. . The Pharma Innovation Journal. 2015; 4(2): 07-08.