Vol. 4, Issue 1 (2015)
Differential Access to Treating Of Drug-Induced Hepatotoxicity in Patients with Chronic Lymphocytic Leukemia
In this article abilities of differential administration of hepatoprotective medications are observed regarding a type of drug-induced liver injury during chemotherapy in patients with chronic lymphocytic leukemia. The type of drug-induced liver injury was determined depending on the grade of increasing of aminotransferase and alkaline phosphatase levels. Effectiveness of arginine glutamate at presence of cytolitic type of drug-induced liver injury and ursosan at presence of cholestatic type of drug-induced liver injury was studied. It was determined that including of these medicines in basic therapy of drug-induced liver injury promotes normalization of biochemical indexes that characterize functional state of liver parenchyma and enables to provide chemotherapy courses of chronic lymphocytic leukemia completely.