Vol. 3, Issue 12 (2015)
Stilbene heterocycles: Synthesis, antimicrobial, antioxidant and anticancer activities
G. Chandrasekara Reddy, S. Shiva Prakash and Latha Diwakar
Stilbenes have long been in focus of scientific interest due to their diverse biological activities. In order to explore molecules possessing superior biological profile, a series of novel stilbene derivatives (9-19) containing pyridine moiety have been synthesized and evaluated for their antimicrobial, antioxidant and anticancer potential. Compounds 11, 16, 17, 18 and 19 exhibited activity against P. aeruginosa (MIC = 50 µg/mL) on par with ampicillin. With regards to fungicidal activity against C. albicans, compounds 11, 13 and 14 showed comparable activity with nystatin (MIC = 3.1 µg/mL). Further, compounds 17 and 19 possess good antioxidant properties. In addition, compound 19 exhibited strong anticancer activity with IC50 values of 12.38 ± 6.83 µM and 14.52 ± 2.21 µM against two cancer cell lines PC-3 and MCF-7 respectively. Thus, compound 3-Bromo-3', 4'-dihydroxy stilbene-2-nitrogen (19) may be considered a lead molecule possessing diverse biological activity for further development.
How to cite this article:
G. Chandrasekara Reddy, S. Shiva Prakash and Latha Diwakar. . The Pharma Innovation Journal. 2015; 3(12): 24-30.