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Vol. 3, Issue 11 (2015)

Formulation development of theophylline in coated polymeric pellets for controlled oral drug delivery

Author(s):
Nicholas C. Obitte and Abali Sunday Okorie
Abstract:
This work is aimed at producing theophylline pellets for controlled oral drug delivery. Eight batches of theophylline pellets were prepared containing varying combinations (2.5 – 10% w/w) of sodium carboxymethyl cellulose, ethylcellulose and eudragit L-100 55. The flow properties of the pellets were determined and batches II and IV, which had the best flow were coated up to 30 – 60% using eudragit L-100. Sequential dissolution studies were carried out on the coated pellets in simulated gastric fluid (SGF), pH 1.2; simulated intestinal fluid (SIF), pH 6.8 and stimulated colonic fluid (SCF), pH 7.4. The dissolution data were subjected to kinetic treatment. The 30% coated pellets released uniform amounts of theophylline in the three media unlike the other batches. Though the coated pellets had the same super case-II transport mechanism of drug release, their release kinetics were different. The 30% coated batch-II pellets had the best controlled oral delivery of theophylline.
Pages: 01-05  |  635 Views  12 Downloads
How to cite this article:
Nicholas C. Obitte and Abali Sunday Okorie. Formulation development of theophylline in coated polymeric pellets for controlled oral drug delivery. 2015; 3(11): 01-05.
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