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Vol. 3, Issue 6 (2014)

Redox-dependent Markers for Response to Neoadjuvant Radiotherapy for Rectal Cancer

Author(s):
Volodymyr V. Golotyuk, Anatoliy P. Burlaka
Abstract:
Biopsy materials of tumors and urine samples from 26 patients with rectal adenocarcinoma of the stage Т2-4N0M0 have been examined. In the first phase of treatment, patients received a preoperative course of radiotherapy to ​​the tumor to a total focal dose of 39 Gy (single focal dose 3 Gy with 13 sessions during 2.5 weeks). A radical surgical intervention was done after 4-5 weeks of treatment. The results of this research single out new prognostic criteria of the tumor radiosensitivity level. Superoxide radicals speed production value before the treatment more than 1,0 nmol/min.·body weight in g. of raw tissue; the low level of the 8-oxoG daily excretion in the urine before the treatment – less than 0,5 nmol/period.·body weight in kg; and the increasing of the 8-oxoG index level in the urine at 50% and more relative to the baseline the day after the beginning of radiotherapy points at the high level of tumor radiosensitivity.
The 8-oxoG excretion level of rectal cancer patients before the treatment in accordance with the degree of pathomorphosis (the mean value, the minimum – the maximum, the trendline).
Fig.: The 8-oxoG excretion level of rectal cancer patients before the treatment in accordance with the degree of pathomorphosis (the mean value, the minimum – the maximum, the trendline).
Pages: 24-27  |  567 Views  6 Downloads
How to cite this article:
Volodymyr V. Golotyuk, Anatoliy P. Burlaka. Redox-dependent Markers for Response to Neoadjuvant Radiotherapy for Rectal Cancer. 2014; 3(6): 24-27.
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