Vol. 2, Issue 12 (2014)

Author(s):
Y. I. Feshchenko, L. O. Iashyna, S. G. Opimakh

Abstract:
This study was performed with the aim to evaluate the possibility of capnometry in efficacy and safety control of CPAP-therapy in chronic obstructive pulmonary disease (COPD) patients with sleep-disordered breathing and hypercapnia. Materials and Methods: For 10 patients with COPD combined with obstructive sleep apnea or obesity hypoventilation syndrome, in whom hypercapnia was observed CPAP-therapy was performed under the control of capnometry. Results: After treatment we observed a statistically significant reduction in CO2 level in the exhaled air of the patients: FECO2 decreased from (4.46 ± 0.13) % to (3.71 ± 0.15) %, FETCO2 from (6.40 ± 0.21) % to (5.63 ± 0.24) %, p < 0.01, which means lower the degree of hypercapnia in patients. Conclusion: Capnometry allow to control efficacy and safety of CPAP-therapy in patients with COPD and hypercapnia with the minimal clinically important difference for FETCO2 is 0.31%.