Volume 3, Issue 8


Effect of natural, synthetic and co-processed excipients on drug release of fluoxetine hydrochloride immediate release drug delivery system

Author: Naresh Reddy Yellamula, Ashok Kumar Appapurapu, Thumma Praveen Kumar Reddy, David Banji, Anil Kumar Appapurapu And Ponnada Nutan Deepthi

Abstract: The purpose of this research was to find out the effect of natural, synthetic and co-processed excipients for the formulation of Fluoxetine hydrochloride immediate release tablet by using different super disintegrants used formulations. Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor drug which is used in psychiatric disorder like depression. Immediate release tablet prepared using various concentrations (1.5%, 3% & 4.5%) of super disintegrants like Moringa oleifera, Crospovidone, Croscaramellose and co-processed excipients like 1:1 ratios Moringa oleifera, Crospovidone and Moringa oleifera, Croscaramellose of by wet granulation method. The pre formulation studies by FTIR confirmed no interactions between drug and polymers. The prepared formulations were evaluated for the pre-compression parameters & the values were within prescribed limits and indicated good free flowing properties. The tablets prepared by wet granulation was evaluated for physical parameters, wetting time, disintegration time, content uniformity and In vitro dissolution, Comparative studies with marketed product, similarity factor. The physical parameters were found to be satisfactory & within the limits. Among the all prepared formulations Moringa oleifera & Crospovidone 1:1 ratio at 4.5% concentration (FW12) by wet granulation method was found to be best formulation as it exhibited satisfactory physical parameters, least disintegration time (30 sec.), wetting time (16 sec.) & highest % drug release (99.5%) at 30 minutes. And its having similarity factor 86 and differentiation factor 6 with marketed product.


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