Volume 3, Issue 5


Effect of Antioxidant Therapy on Endogenous Intoxication Mechanism in Patients with Intestinal Obstruction and at Experiment

Author: V. Skrypko, O. Deltcova, A. Klymenko, M. Gonchar, P. Sheviak

Abstract: The relationship between the level of indicators of lipid peroxidation (LPO), the level of middle weight molecules (MWM), and changes in the structure of the liver and the impact on them Reamberin solution in 102 patients with acute intestinal obstruction (AIO) and model of the obstruction of the small intestine (SIO) in 40 Vietnamese pigs were analyzed. During AIO we founded of  increase of lipid peroxidation products in serum, MWM, and decreased ceruloplasmin securities, significant changes in the liver (destruction of grained and smooth endoplasmic reticulum, mitochondria, nuclei of hepatocytes). Surgical resolution of AIO leads to further deterioration of the temporary structure of the liver, increasing MWM, and indices of lipid peroxidation and decrease of ceruloplasmin levels. Use of antioxidant therapy in the postoperative period promotes reparative processes in hepatocytes and leads to normalization of serum parameters of endogenous intoxication and helps reduce of postoperative mortality.

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